Trimethyl orthoisobutyrate is primarily used as a chemical intermediate in organic synthesis. It plays a key role in the production of various esters and other derivatives, which are essential in the manufacture of flavors, fragrances, and pharmaceuticals. The compound is also utilized in the synthesis of specialty chemicals, where its reactivity and stability make it a valuable building block. Additionally, it finds application in the development of polymer materials, contributing to the creation of resins and coatings with specific properties. Its use in research and industrial processes highlights its versatility in facilitating complex chemical transformations.