4-(tert-Butoxycarbonyl)benzoic acid
95%
Reagent
Code: #145504
CAS Number
20576-82-3
blur_circular Chemical Specifications
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Molecular Information
Weight
222.24 g/mol
Formula
C₁₂H₁₄O₄
thermostat
Physical Properties
Melting Point
209-212°C
Boiling Point
351.8°C
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used as an intermediate in organic synthesis, particularly in the pharmaceutical industry for the preparation of active pharmaceutical ingredients (APIs). It serves as a protected form of 4-carboxybenzoic acid, where the tert-butoxycarbonyl (Boc) group acts as a protecting group for carboxylic acid functionalities during peptide synthesis and other multi-step syntheses. This allows selective reaction at other sites in the molecule without interference from the carboxylic acid group. After the desired transformations are complete, the Boc group can be easily removed under mild acidic conditions to regenerate the free carboxylic acid. Also employed in the synthesis of esters, amides, and heterocyclic compounds due to its stability and ease of handling.
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