Estradiol 3-sulfamate is primarily investigated for its potential use in hormone replacement therapy (HRT), particularly for managing symptoms of menopause such as hot flashes, vaginal dryness, and osteoporosis. Its sulfamate group enhances its bioavailability and prolongs its activity, making it a promising candidate for sustained estrogenic effects. Additionally, it has been studied for its potential neuroprotective properties, with research exploring its role in mitigating cognitive decline and neurodegenerative diseases like Alzheimer’s. The compound’s unique structure also allows it to act as a selective estrogen receptor modulator (SERM), offering targeted therapeutic benefits with reduced side effects compared to traditional estrogens. Its application in cancer therapy, particularly in hormone-sensitive cancers like breast cancer, is also under investigation due to its ability to modulate estrogen receptor activity.