(±)13-HDHA is primarily studied for its potential role in inflammation resolution and immune response modulation. It is a derivative of docosahexaenoic acid (DHA) and is involved in the biosynthesis of specialized pro-resolving mediators (SPMs), which help in reducing inflammation and promoting tissue repair. Research suggests its application in managing chronic inflammatory conditions such as arthritis, cardiovascular diseases, and neurodegenerative disorders. Additionally, it is being explored for its neuroprotective effects, particularly in conditions like Alzheimer’s disease and other cognitive impairments. Its role in skin health is also under investigation, with potential benefits in managing inflammatory skin conditions like psoriasis and eczema. Further studies are ongoing to fully understand its therapeutic potential and applications in various medical fields.