O,O'-Diethyl dithiophosphate is widely used as a flotation agent in the mining industry, particularly for the extraction of sulfide ores. It acts as a collector, selectively binding to sulfide minerals and enhancing their separation from the ore matrix. This compound is also employed as a corrosion inhibitor in lubricants and metalworking fluids, where it forms a protective layer on metal surfaces, reducing wear and extending equipment life. Additionally, it serves as an intermediate in the synthesis of organophosphorus compounds, which are utilized in various industrial and agricultural applications, including pesticides and flame retardants.