Octafluoronaphthalene is primarily used in specialized chemical research and industrial applications due to its unique fluorinated structure. It serves as a key intermediate in the synthesis of advanced materials, particularly in the development of fluorinated polymers and liquid crystals, which are essential in electronics and display technologies. Its high thermal stability and chemical resistance make it suitable for use in high-performance coatings and lubricants. Additionally, it is employed in organic synthesis as a fluorinating agent or building block for creating complex fluorinated compounds. In analytical chemistry, it is sometimes used as a reference standard in gas chromatography and mass spectrometry due to its distinct properties.