4,4,4-Trifluorocrotonic acid is primarily used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Its trifluoromethyl group enhances the biological activity and stability of the compounds it helps create. It is also employed in the development of specialty chemicals, such as liquid crystals and polymers, where its unique properties contribute to improved performance. Additionally, it serves as an intermediate in the synthesis of fluorinated organic compounds, which are valued for their resistance to degradation and their ability to interact selectively in biological systems.