Dimethyl 4-fluorophthalate is primarily used in the synthesis of advanced organic compounds, particularly in the development of pharmaceuticals and agrochemicals. Its fluorinated aromatic structure makes it a valuable intermediate in creating molecules with specific biological activities.

In pharmaceutical research, it serves as a building block for designing drugs targeting various diseases, including cancer and neurological disorders. The fluorine atom enhances the metabolic stability and bioavailability of the resulting compounds.

Additionally, it finds application in material science, where it is utilized to develop specialty polymers and coatings with unique properties such as improved durability, chemical resistance, and thermal stability.

Its role in organic synthesis also extends to the production of liquid crystals and dyes, where its structural properties contribute to the desired optical and electronic characteristics.