Tetrabutylammonium fluoride solution is widely used in organic synthesis as a source of fluoride ions, particularly for desilylation reactions. It effectively removes silyl protecting groups from molecules, making it valuable in the synthesis of complex organic compounds, including pharmaceuticals and natural products. Additionally, it serves as a catalyst or reagent in various fluorination reactions, enabling the introduction of fluorine atoms into organic molecules, which is crucial in drug development due to the unique properties fluorine imparts. Its application extends to material science, where it is used in the preparation of silicon-based materials and surface modifications. The solution is also employed in analytical chemistry for sample preparation and derivatization processes.