AcS-PEG6-OH is widely utilized in bioconjugation and drug delivery systems due to its bifunctional properties. The thiol-reactive acetylthio (AcS) group enables selective conjugation with thiol-containing biomolecules, such as proteins or peptides, while the hydroxyl (OH) group provides a site for further functionalization or attachment to other molecules. Its polyethylene glycol (PEG) spacer enhances solubility, reduces immunogenicity, and improves the stability of conjugated compounds. This makes it particularly valuable in the development of targeted therapeutics, where it helps in creating stable and efficient drug-carrier complexes. Additionally, it is employed in the synthesis of crosslinkers for surface modification, enabling the creation of biocompatible coatings for medical devices or nanoparticles. Its versatility also extends to research applications, such as the study of protein interactions and the development of biosensors.