Aminooxy-PEG2-methane is widely utilized in bioconjugation and chemical biology for its unique reactivity with carbonyl groups. It is particularly effective in linking biomolecules, such as proteins, peptides, or antibodies, to other molecules or surfaces. This compound is often employed in the development of antibody-drug conjugates (ADCs), where it facilitates the attachment of therapeutic agents to antibodies, enhancing targeted drug delivery. Additionally, it is used in the modification of biomaterials and surfaces to improve biocompatibility or introduce specific functional groups. Its role in glycan labeling and analysis is also notable, as it reacts with sugars to enable the study of glycosylation patterns in biological systems. This makes it a valuable tool in research and therapeutic applications.