Used primarily in bioconjugation and chemical synthesis, it serves as a crosslinking agent to attach polyethylene glycol (PEG) chains to biomolecules like proteins, peptides, or antibodies. This enhances their stability, solubility, and reduces immunogenicity, making it valuable in drug delivery systems and therapeutic applications. The pentafluorophenyl (PFP) ester group reacts efficiently with amines, enabling precise and controlled modifications. It is also employed in surface modification of materials to improve biocompatibility for biomedical devices or nanoparticles. Its role in creating PEGylated compounds is critical in developing long-acting pharmaceuticals and targeted therapies.