m-PEG8-Ms is widely used in the field of bioconjugation and drug delivery. Its primary application involves modifying biomolecules, such as proteins, peptides, and antibodies, to enhance their solubility, stability, and bioavailability. The methanesulfonate (Ms) group acts as a reactive handle, enabling efficient attachment to target molecules, while the polyethylene glycol (PEG) chain provides biocompatibility and reduces immunogenicity. This makes it particularly valuable in the development of therapeutic agents, where it helps prolong circulation time in the bloodstream and minimizes potential side effects. Additionally, it is employed in the synthesis of PEGylated prodrugs and in the surface modification of nanoparticles for targeted drug delivery systems. Its versatility also extends to research applications, where it is used to study molecular interactions and improve the performance of diagnostic tools.