N-Boc-PEG5-bromide is widely used in organic synthesis and bioconjugation due to its reactive bromide group and polyethylene glycol (PEG) spacer. It serves as a key intermediate in the preparation of PEGylated compounds, which are essential in drug delivery systems to enhance solubility, stability, and bioavailability of therapeutic agents. The Boc (tert-butoxycarbonyl) protecting group allows for selective deprotection, enabling further functionalization in multi-step synthetic processes. This compound is particularly valuable in the development of prodrugs, bioconjugates, and polymer-based materials, where the PEG chain provides biocompatibility and reduced immunogenicity. Additionally, it is utilized in the synthesis of peptide and protein conjugates, facilitating the attachment of bioactive molecules to PEG for improved pharmacokinetic properties. Its versatility makes it a crucial reagent in pharmaceutical research and material science.