Tr-PEG8-OH is widely used in bioconjugation and chemical synthesis due to its hydrophilic and flexible polyethylene glycol (PEG) spacer. It serves as a linker in drug delivery systems, enhancing the solubility and stability of therapeutic compounds. In bioconjugation, it facilitates the attachment of biomolecules, such as peptides or proteins, to other entities like nanoparticles or drugs, improving their pharmacokinetics and reducing immunogenicity. Additionally, it is employed in the development of hydrogels and biomaterials, where its PEG chain provides biocompatibility and controlled release properties. Its application extends to diagnostics, where it is used to modify surfaces for improved sensitivity and specificity in assays.