This chemical is primarily used in the field of bioconjugation and click chemistry due to its reactive propargyl group. It serves as a versatile linker for attaching polyethylene glycol (PEG) chains to biomolecules, such as proteins, peptides, or antibodies, enhancing their solubility, stability, and circulation time in biological systems. The trifluoroethyl group provides additional chemical stability and can influence the hydrophobicity of the resulting conjugate. Its application is significant in drug delivery systems, where PEGylation improves the pharmacokinetics and therapeutic efficacy of drugs. Additionally, it is utilized in the development of diagnostic probes and imaging agents, enabling precise targeting and detection in biomedical research.