F-PEG2-COOH is widely used in bioconjugation and drug delivery systems due to its bifunctional nature. The fluorine atom allows for easy incorporation into various molecules, while the PEG (polyethylene glycol) spacer enhances solubility and reduces immunogenicity. The carboxyl group (-COOH) enables covalent attachment to biomolecules such as proteins, peptides, or antibodies, making it valuable for creating targeted therapeutics. It is also employed in the development of fluorescent probes and imaging agents, where the PEG linker improves stability and biocompatibility. Additionally, this compound is utilized in surface modification of nanoparticles to enhance their circulation time in biological systems. Its versatility makes it a key component in pharmaceutical research and nanotechnology applications.