HO-PEG-AC is widely used in bioconjugation and drug delivery systems due to its reactive acrylate (AC) group and hydrophilic polyethylene glycol (PEG) chain. The acrylate group allows for efficient coupling with thiol-containing molecules, making it valuable for creating stable covalent bonds in protein modification, surface functionalization, and polymer synthesis. Its PEG component enhances solubility, reduces immunogenicity, and prolongs circulation time in biological systems, making it ideal for developing therapeutic nanoparticles, hydrogels, and targeted drug delivery vehicles. Additionally, HO-PEG-AC is utilized in tissue engineering for creating biocompatible scaffolds and in diagnostics for labeling biomolecules. Its versatility and biocompatibility make it a key material in biomedical research and applications.