SH-PEG-SH is widely used in bioconjugation and surface modification due to its thiol-reactive ends. It serves as a crosslinker in the development of drug delivery systems, enabling the attachment of therapeutic agents to carriers like nanoparticles or proteins. In tissue engineering, it facilitates the creation of biocompatible scaffolds by linking biomolecules to enhance cell adhesion and growth. Additionally, it is employed in the functionalization of gold nanoparticles for biosensing applications, improving stability and targeting capabilities. Its role in stabilizing proteins and peptides in biopharmaceutical formulations is also notable, ensuring enhanced efficacy and shelf life.