2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
97%
Reagent
Code: #163739
CAS Number
1013916-37-4
blur_circular Chemical Specifications
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Molecular Information
Weight
263.72 g/mol
Formula
C₁₃H₁₄ClN₃O
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Registry Numbers
MDL Number
MFCD13181207
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Physical Properties
Boiling Point
428.0±34.0 °C at 760 mmHg
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Storage & Handling
Storage
Room temperature, inert gas
description Product Description
Used as a key intermediate in the synthesis of cyclin-dependent kinase (CDK) inhibitors, particularly in the development of anticancer agents. Its structure allows selective binding to CDK enzymes, making it valuable in targeted cancer therapies. It has been studied in the context of inhibiting CDK2 and CDK4, which play critical roles in cell cycle regulation. Due to its ability to cross cell membranes and exhibit good metabolic stability, it is favored in medicinal chemistry for optimizing drug candidates aimed at treating solid tumors and hematological malignancies.
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