SB-222200 is primarily used in research settings as a selective antagonist for the NK3 receptor, which is a type of neurokinin receptor found in the central and peripheral nervous systems. Its application is significant in studying the role of neurokinin B and NK3 receptors in various physiological processes, including reproductive functions, mood regulation, and pain perception. Researchers utilize SB-222200 to investigate its potential therapeutic effects in conditions such as depression, anxiety, and certain pain disorders. Additionally, it is employed in preclinical studies to understand the mechanisms underlying hormone release, particularly in the context of the hypothalamic-pituitary-gonadal axis. Its selectivity makes it a valuable tool for dissecting the specific contributions of NK3 receptors in complex biological systems.