WAY-325282 is a potent and selective antagonist of the orexin receptor 2 (OX2R). It has been primarily investigated for its potential in treating sleep disorders, particularly insomnia. By blocking the orexin signaling pathway, which plays a key role in promoting wakefulness, WAY-325282 helps facilitate sleep onset and improve sleep maintenance. Its selectivity for OX2R over OX1R makes it a valuable tool in understanding the distinct roles of orexin receptors in regulating sleep-wake cycles. Due to its pharmacological profile, it has served as a research compound in preclinical studies aimed at developing new dual and selective orexin receptor antagonists for therapeutic use. While not marketed as a drug, its application remains significant in neuroscience research and drug discovery efforts targeting sleep and arousal mechanisms.