WAY-213613 hydrochloride is primarily used in scientific research as a potent and selective antagonist for the orexin-1 receptor (OX1R). It is employed to study the role of orexin signaling in various physiological processes, particularly those related to sleep-wake regulation, feeding behavior, and addiction. Due to its high selectivity, it helps researchers differentiate the functions of orexin receptor subtypes in neurological pathways. The compound is valuable in preclinical studies investigating sleep disorders such as insomnia and narcolepsy, as well as conditions involving dysregulated reward mechanisms, including drug dependence and obesity. Its application remains confined to laboratory and experimental settings, with no current use in clinical medicine.