WAY-326766 is primarily used in scientific research for its potent and selective antagonistic activity at the orexin receptor type 1 (OX1R). It serves as a pharmacological tool to investigate the role of the orexin system in regulating sleep-wake cycles, feeding behavior, and arousal. Due to its ability to cross the blood-brain barrier, it is valuable in central nervous system studies, particularly in models of insomnia, narcolepsy, and addiction. Researchers utilize WAY-326766 to dissect the contributions of OX1R signaling in behavioral responses and stress-related pathways, making it a key compound in developing potential therapeutics for sleep and neuropsychiatric disorders.