Plecanatide acetate is primarily used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It works by increasing fluid secretion in the intestines, which helps to soften stools and promote bowel movements. This makes it effective in alleviating symptoms such as straining, bloating, and abdominal discomfort associated with these conditions. The medication is taken orally, typically once daily, and is designed to act locally in the gastrointestinal tract with minimal systemic absorption, reducing the risk of side effects. Its targeted mechanism of action provides a reliable option for patients seeking relief from chronic constipation-related issues.