Glucagon receptor antagonists are primarily used in the management of type 2 diabetes. They work by blocking the action of glucagon, a hormone that raises blood glucose levels. By inhibiting the glucagon receptor, these antagonists help reduce excessive glucose production in the liver, thereby improving blood sugar control. This makes them a valuable therapeutic option for patients who struggle to maintain optimal glucose levels despite using other diabetes medications. Additionally, they may be explored for their potential in treating conditions like hyperglycemia and metabolic disorders. Research is ongoing to further understand their efficacy and safety in broader clinical applications.