PHCCC is primarily used in research settings to study the role of metabotropic glutamate receptors (mGluRs) in the nervous system. It acts as a positive allosteric modulator of mGluR4, a receptor involved in regulating neurotransmitter release and synaptic plasticity. This makes it a valuable tool for investigating neurological disorders such as Parkinson's disease, where mGluR4 modulation has shown potential therapeutic effects. Additionally, PHCCC is utilized in studies exploring its impact on anxiety, depression, and other mood-related conditions, as mGluRs play a significant role in emotional regulation. Its application extends to understanding the mechanisms of neuroprotection and potential drug development targeting glutamate signaling pathways.