ACY-775 is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), primarily explored for its potential in neurological research, particularly in studying neurodegeneration and axonal transport. It promotes the acetylation of alpha-tubulin, enhancing microtubule stability and supporting neuronal health. Researchers use ACY-775 to investigate its effects in models of Charcot-Marie-Tooth disease, Alzheimer's disease, peripheral neuropathy, and other cognitive or neurodegenerative disorders. Additionally, it is studied for its ability to improve synaptic plasticity, memory retention, and recovery in brain injury models. Its application in these areas could lead to the development of novel treatments targeting neurological impairments.