UPF-648 is primarily utilized in neuroscience research, particularly in the study of glutamate transporters. It serves as a selective inhibitor of excitatory amino acid transporter 2 (EAAT2), which plays a crucial role in regulating glutamate levels in the central nervous system. By inhibiting EAAT2, UPF-648 helps researchers investigate the physiological and pathological roles of glutamate, such as its involvement in neurodegenerative diseases, stroke, and epilepsy. This compound is valuable for understanding glutamate dynamics and developing potential therapeutic strategies targeting glutamate-related disorders.