(R)-Elagolix is a synthetic gonadotropin-releasing hormone (GnRH) receptor antagonist primarily used in the treatment of endometriosis and uterine fibroids. It works by inhibiting the release of GnRH from the hypothalamus, which reduces the production of certain hormones, such as estrogen and progesterone, helping to alleviate the pain and symptoms associated with these conditions. This medication is often prescribed for women who have not responded well to other treatments or who require a non-surgical option. It is taken orally and is typically part of a comprehensive treatment plan that may include lifestyle changes and other therapies. It may also be used for abnormal uterine bleeding in women with uterine fibroids. Regular monitoring by a healthcare provider is essential to manage potential side effects, such as hot flashes and decreased bone density, and ensure the medication's effectiveness.