3,4,5-Trifluoro-2-hydroxybenzoic acid
98%
Reagent
Code: #130467
CAS Number
205533-30-8
blur_circular Chemical Specifications
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Molecular Information
Weight
192.09 g/mol
Formula
C₇H₃F₃O₃
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Registry Numbers
MDL Number
MFCD20640463
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Physical Properties
Melting Point
148-150 °C(Solv: toluene (108-88-3))
Boiling Point
289.9±40.0 °C(Predicted)
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Storage & Handling
Density
1.699±0.06 g/cm3(Predicted)
Storage
Room temperature, seal, dry
description Product Description
Used as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. Its trifluorinated aromatic structure enhances metabolic stability and membrane permeability in drug candidates. Commonly employed in medicinal chemistry for structure-activity relationship (SAR) studies due to the electron-withdrawing effects of fluorine atoms, which influence acidity and binding affinity. Also utilized in the preparation of agrochemicals and specialty polymers where fluorination improves thermal and oxidative resistance.
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