Clethodim sulfone is the primary active metabolite of the herbicide clethodim, used in agriculture for selective post-emergence control of annual and perennial grassy weeds in broadleaf crops such as soybeans, cotton, peanuts, and sugar beets. It functions by inhibiting acetyl-CoA carboxylase (ACCase), disrupting fatty acid synthesis essential for cell membrane formation and plant growth, particularly affecting meristematic tissues and leading to weed death. This metabolite contributes to the prolonged herbicidal activity of clethodim, enabling season-long weed management. It exhibits good selectivity for crops when applied at recommended rates and is typically formulated with adjuvants to improve foliar uptake and efficacy.