Thioperamide is primarily used in research settings to study the role of histamine receptors, particularly H3 and H4 receptors, in various physiological and pathological processes. It acts as a potent and selective antagonist of these receptors, making it a valuable tool for understanding their function in the central nervous system and immune system. In neuroscience, it helps investigate the regulation of neurotransmitter release, particularly histamine, dopamine, and acetylcholine, which are critical for cognitive functions, sleep-wake cycles, and appetite regulation. Additionally, Thioperamide is utilized in studies exploring its potential therapeutic applications in conditions like sleep disorders, obesity, and inflammatory diseases due to its ability to modulate histaminergic pathways. Its role in immune modulation is also of interest, particularly in allergic responses and autoimmune disorders.