Pitolisant is primarily used in the treatment of narcolepsy, a chronic sleep disorder characterized by excessive daytime sleepiness and sudden episodes of muscle weakness (cataplexy). It works by enhancing histamine signaling in the brain, which promotes wakefulness and alertness. This makes it an effective option for patients who struggle with maintaining normal wakefulness during the day.

Additionally, Pitolisant has shown potential in managing other conditions related to excessive sleepiness, such as obstructive sleep apnea and idiopathic hypersomnia. Its unique mechanism of action, which differs from traditional stimulants, offers a lower risk of abuse and dependence, making it a safer long-term treatment option for chronic sleep disorders.

In some cases, Pitolisant is also being explored for its potential benefits in addressing cognitive impairments and fatigue associated with neurological conditions like Parkinson’s disease and multiple sclerosis. Its ability to modulate histamine levels in the brain may contribute to improved cognitive function and reduced fatigue in these patients. Overall, Pitolisant represents a versatile therapeutic agent with expanding applications in sleep and neurological disorders.