VUF10460 is primarily utilized in research settings as a selective antagonist for the histamine H4 receptor. Its application is significant in studying inflammatory and immune responses, as the H4 receptor plays a role in mediating these processes. Researchers use it to explore potential therapeutic targets for conditions like asthma, allergic reactions, and chronic inflammatory diseases. Additionally, it aids in understanding the receptor's role in pain modulation and its involvement in certain autoimmune disorders. Its selectivity makes it a valuable tool for dissecting the complex pathways associated with histamine signaling in the body.