tert-Butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate
97%
Reagent
Code: #145427
CAS Number
124655-09-0
blur_circular Chemical Specifications
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Molecular Information
Weight
260.33 g/mol
Formula
C₁₃H₂₄O₅
thermostat
Physical Properties
Boiling Point
330.9°C
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key chiral building block in the synthesis of statin-class cholesterol-lowering drugs. Its protected hydroxyl groups and defined stereochemistry allow for selective chemical transformations, enabling efficient construction of complex drug molecules. Commonly employed in pharmaceutical research and development to introduce the side chain found in atorvastatin and similar HMG-CoA reductase inhibitors. The isopropylidene group stabilizes the intermediate during synthesis and is later removed under mild acidic conditions. Valued for high enantiomeric purity and compatibility with multi-step synthetic routes.
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