Used in hormone replacement therapy to manage symptoms of menopause such as hot flashes, vaginal dryness, and mood changes. It acts as a prodrug, slowly releasing active estrogen in the body for sustained effect. Also under research for potential use in treating certain hormone-sensitive cancers due to its targeted delivery and reduced systemic side effects. Its sulfamate modification enhances absorption through the skin, making it suitable for transdermal formulations. Additionally, it may offer benefits in maintaining bone density and reducing the risk of osteoporosis in postmenopausal women.