Corticotropin Releasing Factor (CRF) from sheep is primarily used in research settings to study stress responses and the hypothalamic-pituitary-adrenal (HPA) axis. It is employed to investigate the mechanisms of stress-related disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD). Researchers use it to stimulate the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, helping to understand the regulation of cortisol and other stress hormones. Additionally, it is utilized in studies exploring the role of CRF in appetite regulation, immune function, and gastrointestinal disorders. Its application extends to preclinical models to evaluate potential therapeutic interventions targeting the CRF system.