Used in research to study endothelin receptor interactions and vascular biology. Helps investigate conditions related to blood pressure regulation, cardiovascular diseases, and endothelial function. Due to its modified structure, it serves as a tool compound for probing receptor subtype selectivity, particularly in distinguishing between ETA and ETB receptors. Also utilized in pharmacological studies aiming to develop therapeutic agents targeting endothelin pathways, such as treatments for pulmonary arterial hypertension, chronic kidney disease, and certain cancers.