Metrizamide is primarily used as a contrast agent in medical imaging, particularly in myelography, to enhance the visibility of the spinal cord and nerve roots during X-ray or CT scans. It is also employed in cisternography to visualize the subarachnoid spaces and ventricles of the brain, aiding in the diagnosis of conditions like cerebrospinal fluid leaks or hydrocephalus. Additionally, metrizamide is utilized in some diagnostic procedures for the inner ear and in certain types of angiography. Its high solubility and low toxicity make it suitable for these applications, ensuring clear imaging while minimizing risks to patients.