Used in biomedical research to measure levels of cAMP response element-binding protein (CREB) in rat tissue samples or cell lysates. This ELISA kit enables researchers to quantify phosphorylated or total CREB protein, helping study intracellular signaling pathways linked to gene expression, neuronal function, memory formation, and cellular responses to hormones or growth factors. Commonly applied in neuroscience, endocrinology, and pharmacology studies where activation states of CREB are critical indicators of cellular activity. The assay provides a sensitive and specific method for high-throughput analysis in experimental models involving stress, learning, addiction, or neurodegenerative diseases.