Used in biomedical research to quantify HMGB-2 protein levels in mouse tissue samples and biological fluids. Enables study of inflammation, cell death, and immune responses in experimental models. Commonly applied in research on sepsis, ischemia-reperfusion injury, and autoimmune diseases. Supports investigation of HMGB-2's role in DNA repair and cancer progression. Provides a sensitive and specific method for monitoring protein release during cellular stress.