Used in biomedical research to quantify levels of large endothelin (BigET) in mouse samples, this ELISA kit enables the study of endothelial function and vascular regulation in experimental models. It is particularly valuable in cardiovascular research, including hypertension, heart failure, and pulmonary arterial hypertension studies. The assay helps assess endothelin system activation, providing insights into disease mechanisms and therapeutic interventions targeting endothelin pathways. Due to its specificity and sensitivity, it supports reliable measurement of BigET in serum, plasma, and cell culture supernatants, facilitating longitudinal and mechanistic investigations in mouse models.