Used in biomedical research to detect and quantify cytokeratin 18 fragments in serum or plasma samples, this ELISA kit serves as a tool for assessing epithelial cell death. It is particularly valuable in studies related to liver diseases such as non-alcoholic steatohepatitis (NASH), drug-induced liver injury, and viral hepatitis, where elevated levels of CK-18 indicate ongoing apoptosis. Researchers also use it in cancer studies to monitor tumor response to therapy, especially in carcinomas of epithelial origin. The assay helps differentiate between apoptotic and necrotic cell death, supporting the evaluation of disease progression and treatment efficacy in clinical and preclinical settings.