Used in immunological research to detect and quantify cold agglutinins in human serum and plasma samples. The kit enables the measurement of immunoglobulins that precipitate at lower temperatures, which is particularly useful in studying autoimmune disorders, cold agglutinin disease, and certain infections like Mycoplasma pneumoniae or Epstein-Barr virus. It supports clinical research by providing a reliable method to assess abnormal immunoglobulin behavior under cold conditions, aiding in the understanding of disease mechanisms and immune response variations.