Used in bone metabolism research to quantify C-terminal telopeptide fragments of type I collagen in biological samples, serving as a biomarker for bone resorption. Enables assessment of osteoclast activity and bone turnover rates in preclinical studies. Commonly applied in osteoporosis, metabolic bone disease, and drug development research to evaluate the efficacy of anti-resorptive therapies. Provides a sensitive and specific method for high-throughput screening in serum, plasma, or cell culture samples.