Used in research to quantify cartilage degradation by measuring C-terminal cross-linked telopeptides of type II collagen in biological samples such as serum or urine. Helps assess joint tissue breakdown in conditions like osteoarthritis and rheumatoid arthritis. Commonly applied in preclinical and clinical studies to monitor disease progression and evaluate efficacy of therapeutic interventions targeting cartilage metabolism. Provides a non-invasive method to study bone and cartilage turnover, supporting biomarker development in musculoskeletal research.