Used in biomedical research to detect and quantify soluble ST2 protein levels in human serum, plasma, and cell culture supernatants. Helps in assessing immune responses and inflammation, particularly in cardiovascular diseases such as heart failure, where elevated ST2 levels correlate with disease severity and prognosis. Also applied in asthma and other Th2-mediated inflammatory conditions to monitor disease progression and therapeutic response. Enables researchers to study the IL-33/ST2 signaling pathway’s role in fibrosis, allergy, and autoimmune disorders.