Used in biomedical research to detect and quantify IRE1 protein levels in cell lysates or tissue samples. Helps study endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) pathway, which are involved in diseases like diabetes, neurodegenerative disorders, and cancer. Enables researchers to assess IRE1 activation under various experimental conditions, supporting drug development and mechanistic studies in cellular stress responses.