Used in bone metabolism studies to quantify osteoclast differentiation factor, a key regulator in osteoclast formation and activation. Enables researchers to assess bone resorption activity in experimental models of osteoporosis, arthritis, and other bone-related diseases. Commonly applied in preclinical drug development to evaluate the efficacy of anti-resorptive therapies. Supports investigation into cytokine signaling pathways involved in bone remodeling, particularly RANK/RANKL interactions. Ideal for cell culture supernatants, serum, and tissue lysates in biomedical research settings.